MARK NOE  VP, Discovery Technologies

EDUCATION: Ph.D. Synthetic Organic Chemistry, Harvard University with E. J. Corey

EXPERIENCE: 1996-2025: Pfizer – Discovery Technologies, Infectious Diseases, Inflammation, Oncology

EXPERTISE: Technology development and implementation for: hit ID, confirming mechanism of action, characterizing molecular mode of action, in vitro ADME characterization, chemical biology, structural biology, analytical chemistry, compound management, functional genomics.  Drug design and synthesis.  Due diligence reviews for inlicensing and business development.  Over 80 publications and patents.

BIO: Mark worked as a medicinal chemist and research group leader at Pfizer for 29 years, where he led Discovery Sciences, an interdisciplinary department enabling hit identification and drug design across the small molecule and vaccines portfolio.  This group made important contributions to several marketed products, including Abrysvo, Comirnaty, Paxlovid, Litfulo and Cibinqo.  Under his leadership, structural biology was transformed through integration of cryo-EM and AI-driven protein construct design to enable structure based design at the time of HTS triage, compound management transitioned from conventional liquid handling to acoustic dispensing from plate- and tube-based sources, DNA Encoded Libraries became a cornerstone for hit identification, new screening methods for protein homeostasis modulators were introduced along with streamlined methods for determining their mechanism of action, and acoustic echo mass spectrometry applications in high throughput screening were developed.  He also has extensive experience in the infectious disease therapeutic area, where he headed antibiotic medicinal chemistry for 8 years and briefly served as chief scientific officer of infectious disease.  Mark serves on scientific advisory boards for several academic institutions, including the Monash Institute of Pharmaceutical Sciences, the University of Michigan Drug Discovery Institute and the Roswell Park Cancer Center Department of Immunology Graduate Research Program.